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This pain sensitizing effect of MSG was not observed in the temporalis muscle, suggesting that the effect was site specific.
However, to our knowledge, no study has examined whether changes in muscle transcripts contribute to the insulin sensitizing effect of TZDs in PCOS patients.
The USRDS 2010 annual report confirmed the sensitizing effect of transfusions.
A study in isolated adult rat ventricular myocytes reported a mild myofilament Ca2+ sensitizing effect of diltiazem [ 9].
In the third cell line, KMS-12-BM, there was a moderate sensitizing effect of TNF on both TRAIL- and CD95L-induced cell death.
These results suggest that the insulin sensitizing effect of thiazolidinediones could be partially achieved through repression of adipose tissue macrophage content and subsequent reduction of inflammatory factor production.
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Previous studies demonstrated a potential insulin-sensitizing effect of anti-TNF biologic medications.
Therefore, theoretically the insulin-sensitizing effect of DGAT1 overexpression could be due to reductions in ceramide levels.
These findings suggest that the insulin-sensitizing effect of pioglitazone therapy may include reversal of abnormalities in ribosomal protein biosynthesis and mitochondrial oxidative phosphorylation.
The observation by GSEA that SRA and TNFα regulate a common set of genes in opposite directions further suggests an anti-inflammatory, insulin-sensitizing effect of SRA.
Our data support a drug-sensitizing effect of miR-203.
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