Sentence examples for sensitizing chemicals from inspiring English sources

From data analysis, a biomarker signature of 200 transcripts was identified, which completely separated the response induced by sensitizing chemicals vs. non-sensitizing chemicals and the predictive power of the signature was illustrated, using ROC curves.

The large number of differentially expressed genes in MUTZ-3 cells stimulated with sensitizing chemicals vs. non-sensitizing controls revealed that MUTZ-3 indeed had a capacity to differentiate between these two groups.

In both cases there is a need for predictive test methods that allow the accurate identification of sensitizing chemicals.

As sensitizing chemicals diffuse into the skin, they react with some proteins of the body, changing the antigenic properties of the protein.

Current test of sensitizing chemicals rely on animal experimentation.

Photo sensitizing chemicals absorb ultraviolet (UV) and/or visible radiation, a characteristic that is essential for the chemical to be regarded as a photosensitizer.

To validate the predictive power of our signature, we used a machine learning method called the Support Vector Machine (SVM) [ 12], which maps the data from a training set in space in order to maximize the separation of gene expression induced by sensitizing and non-sensitizing chemicals.

In Figure 6A, the samples of the sensitizing and non-sensitizing chemicals in the test set have been colored dark red and dark green respectively, indicating that they are not contributing to the principal components of the plot, but are merely plotted based on their expression values of the selected Test Gene Signature.

Indeed, the Organisation of Economic Cooperation and Development OECDD) recently recommended the use of the Nrf2-based KeratinoSens™ assay for testing the skin sensitizing potential of chemicals [ 45], emphasizing that the value of monitoring Nrf2 activity for the detection of chemical stress is already being realized in certain settings.

The currently available animal-free methods for the detection of skin sensitizing potential of chemicals seem promising.

Thus, development of reliable in vitro alternatives to experimental animals for the assessment of sensitizing capacity of chemicals is urgent.