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This study demonstrates that functional inhibition of PARG may be useful for sensitizing at least particular cancer cells to alkylating agents.
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We found that ectopic expression of NES-hTERT led to nuclear telomeric, extra-telomeric and mitochondrial DNA (mtDNA) damage in the cancer cells and sensitized at least one type of cancer cells to both oxidative stress and γ-radiation.
Interestingly, although in Italy the population mean of daily intake of peanuts is low (0.05 g/day versus 0.19 g/day in Europe), we found a relevant percentage of patients with peanut genuine sensitization (40% of our patients are sensitized to at least one of the SSPs), and most of them were small children [ 22].
The association with any wheezing was similar among children from farms and from rural/suburban areas as well as children who were sensitized against at least one of the tested inhalant or food allergens at the age of 6 years and who were not sensitized (P-values ≥ 0.4 for interaction terms) (data not shown).
The associations between total microbial quantity score and any wheezing were similar among children who were sensitized against at least one of the tested inhalant or food allergens at the age of 6 years and who were not sensitized (P-value = 0.66 for interaction term).
Almost half of the control group were sensitized to at least one allergen.
Of the 2,477 participants, 400 infants were sensitized to at least one of the 10 tested allergens (Table 1).
More boys than girls were sensitized to at least one allergen (P < 0.01) or had a history of asthma (P = 0.05).
The majority of all reported CIN genes (i.e., 445/692; 64%) were sensitized to at least one of the genome destabilizing drugs.
Three-hundred and nine (15%) and 510 (25%) children were sensitized to at least one of the selected inhalant allergens at 4 and 8 years of age, respectively (P<0.001).
For the subset of 46 children (59%) who underwent allergy testing, 78% were sensitized to at least one of the tested substances, with the most prevalent allergies including D. pteronyssinus (59%), cockroach (59%), D. farinae (50%), and tree pollen (30%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com