Sentence examples for sensitizing activity in from inspiring English sources
Interestingly and somewhat unexpectedly, compound 1, 20-hydroxyecdysone, was also found to show significant and relevant sensitizing activity in case of one cell line, MCF7, when coadministered with paclitaxel.
The radio sensitizing activity of taxanes in vitro however is achieved even at sub-nanomolar concentrations.
It was also found that the main site of the insulin sensitizing activity of ligand activated PPARγ was, in fact, adipose tissue [116].
In the bioassay for insulin sensitizing activities of the isolates, compound 2 significantly stimulated glucose uptake in insulin resistant HepG2 cells without affecting cell viability, showing ability to restore the impaired insulin sensitivity of cells.
In another study, ethanolic crude extract of Sorbus decora demonstrates both anti-hyperglycemic and insulin-sensitizing activity in vivo, thereby confirming anti-diabetic potential and validating traditional medicine [ 29].
Reported herein, was the isolation and structural elucidation of these natural products as well as insulin sensitizing activity of 2. Open image in new window Fig. 1 Structures of compounds 1 12.
Nodal is a potent enhancer of EMT activity (ingression) and sensitizes cells to activity in neighbouring cells (community effect).
Based on our findings, we propose a novel model of PCB developmental neurotoxicity in which noncoplanar PCBs sensitize RyR activity and alter Ca2+-dependent signaling mechanisms that link neuronal activity to dendritic growth and plasticity.
These data linking a direct molecular effect of NDL PCBs (sensitized RyR activity) to disruption of a specific neurodevelopmental event (dendritic arborization) have significant implications for understanding how PCBs interfere with normal neurodevelopment in the human brain.
This study reports the first clinical outcome for insulin sensitizing agents with potential anti-inflammatory activity in the management of CFRD.
Collectively, these findings indicate that dysregulated mTORC1 activity sensitizes cells to JNK activation by ER stress.
