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Which TRAIL-apoptosis sensitizing strategies should be considered for novel therapeutic combinations to overcome TRAIL resistance?
This will allow the development of sensitizing strategies to circumvent adipose tissue-mediated resistance to trastuzumab in breast cancer.
Based on the high potency of CDK9 inhibition as a cancer cell-selective TRAIL-sensitizing strategy, we envisage the development of new, highly effective cancer therapies.
Possibly even more interestingly from a clinical perspective, the authors could utilize their system to propose a case-specific TRAIL-sensitizing strategy by analyzing the expression profiles from individual cell lines.
The only successful sensitizing strategy thus far has been hormonal deprivation in combination with radiation therapy, which has been demonstrated to improve cause-specific survival in men with advanced prostate cancer [ 14, 15], but still hormonal therapy in this setting is not the panacea.
The BARI-2D study (33) showed no benefit of insulin sensitizing strategy on DN in older adults with coronary artery disease and type 2 diabetes, but with a mean age of 62 years and most participants having both hypertension and hyperlipidemia, this is a very different study population than ours (34).
The TiO2 NT array electrodes are sensitized with Mn-CdS and CdSxSe1-x QDs by employing a two-stage sensitization strategy combining successive ionic layer adsorption and reaction (SILAR) techniques and hydrothermal process.
As a result, co-sensitized strategy has been adopted by many researchers.
Nevertheless, the strategy of TiO2 sensitized by the single inorganic semiconductor limited the further improvement of the photoelectric performance and light absorption property.
We believe the implementation strategy may have sensitized the workforce in terms of shortcomings in the services provided, and that this may have caused their self-assessment of quality to go down.
With cardiac insulin resistance and metabolic dysregulation known to precede the development of heart failure (Witteles & Fowler, 2008; Brouwers et al, 2013), strategies sensitizing the heart to glucose uptake may thus have clinically relevant implications in the long-term prognosis of heart failure.
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