Sentence examples for sensitized screening from inspiring English sources

However, because phenotyping of individual knockout lines is expensive and time consuming present screens are aimed at uncovering phenotypes with high penetrance and expressivity and are likely to miss susceptibility phenotypes that require sensitized screening.

Here we used a broad, unbiased and sensitized screening approach to uncover susceptibility to immune, metabolic, cardiac, cancer, and behavioural phenotypes.

Our findings demonstrate the potential of unbiased sensitized screening of segmental aneuploidy lines to identify susceptibility genes for common disease phenotypes in the mouse.

These data demonstrate the potential of unbiased sensitized screening of segmental aneuploidy lines to identify susceptibility genes for common disease phenotypes in the mouse.

In the mouse, focused sensitized screens have been successful at identifying susceptibility mutations using quantitative trait loci (QTL, e.g. modifiers of ApcMin; Dietrich et al, 1993) and chemical mutagenesis (ENU, e.g. Matera et al, 2008; Rubio-Aliaga et al, 2007) approaches.

One efficient approach to identify components of a molecular network is to perform genetic modifier- or sensitized-screens [13].

For the three disease outcome group comparisons, a screening p-value was set at 0.25, below which the pairwise comparisons between groups (definite or probable disease vs. no disease, definite or probable disease vs. sensitized, sensitized vs. no disease) were further investigated.

In chemotherapeutic sensitivity screening assays, cells overexpressing pp32 were selectively resistant to the nucleoside analogs gemcitabine and cytarabine (ARA-C), but were sensitized to 5-fluorouracil; conversely, silencing pp32 in pancreatic cancer cells enhanced gemcitabine sensitivity.

In the future, it might be possible to sensitize the screen by using a genetic background that contains a weak suppressor.

We also considered that ced-5 (n1812 ) might have overly sensitized the primary screen, revealing genes with only marginal roles in gastrulation, roles that could not be confirmed in a nonsensitized background.

The other cell lines were ineffectively sensitized at the preliminary screening.