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As a result, the PPG can either be oxidized by loss of an electron or reduced by accepting an electron in a direct (the protecting group is a chromophore) or sensitized manner.
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We now report that influenza infection induced pulmonary IL-27 production in a type I IFN-α/β receptor (IFNAR) signalling-dependent manner, which sensitized mice to secondary pneumococcal infection downstream of IFNAR pathway.
In our study, we showed that influenza infection induced pulmonary IL-27 production in a type I IFNAR signalling-dependent manner, which sensitized mice to secondary pneumococcal infection downstream of IFNAR pathway.
To do this we isolated effector cells from the spleens of S. Mansoni sensitized mice in the same manner as in Figure 3 and stimulated those cells with recombinant Notch ligands in the presence of anti-CD3 and anti-CD28.
Imagine if the world were sensitized in this way.
Transfection with siRNA against c-Rel sensitized the TRAIL-resistant cells in a manner comparable to siRNA targeting the p65/RelA subunit.
Guinea pigs have been the most commonly used small animal species in preclinical studies related to asthma and COPD [ 29]. β2-adenoceptor agonists and antimuscarinic drugs prevent antigen-induced bronchoconstriction in actively sensitized guinea pigs in a dose-dependent manner.
Likewise telomerase inhibition by small-molecule (BIBR1532) sensitized drug-resistant and drug-sensitive cells to chemotherapeutic treatment in a telomere length dependent manner [26].
Indeed, bradykinin and facial capsaicin injections sensitized TRPA1 via TRPV1 in a Ca2+-dependent manner in cultured trigeminal neurons from mice and rats, leading to inflammatory cold hyperalgesia (Bautista et al., 2006; Honda et al., 2014).
Both the proteins encoded by these alleles sensitized cells to apoptosis in a dose-dependent manner, but EVER2 I306 was significantly less effective than EVER2 N306.
By expanding allergen-specific Tregs and reducing pro-inflammatory effector T cells, these microparticles inhibited destructive hypersensitivity responses to subsequent allergen exposure in an allergen-specific manner, effectively preventing or reversing ACD in previously sensitized mice.
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