The residues cause toxic effects on consumers, such as allergic reactions in sensitive or sensitized individuals, provoke the development of antibiotic-resistant bacteria and may induce cross-resistance against other antibiotics of similar structure or mechanism of action, making it more difficult to treat certain infections [7].
Therefore, it only occurs in previously sensitized individuals and requires a latency period of sensitization and allergic contact dermatitis to prometazine.
Mild, reversible changes in pulmonary function (forced expiratory volume at 1 s and midexpiratory flow) can occur in sensitized individuals at levels approaching 2 ppm.
This risk avoidance strategy maximizes outcomes following transplant, but at the expense of limiting access to transplant for sensitized individuals.
Sensitized individuals have reported contact dermatitis after the use of Al containing deodorants, pharmaceutics (ear drops, antiseptics), sun protectors, tattooing pigments and metallic aluminium [13].
Sensitized individuals may show an allergy to nickel, affecting their skin, known as dermatitis.
In human blood mononuclear cells from mite sensitized individuals, Pam3CSK4 reduced Th2 responses [40], and in whole blood cultures from nematode-infected children Pam3CSK4 was shown to have IL-10 inducing capacity [41].
A TST induced "boosting" of IGRA responses was demonstrated in several studies and although more pronounced in IGRA-positive (i.e. sensitized) individuals, also occurred in a smaller but not insignificant proportion of IGRA-negative subjects.
Sensitized individuals may subsequently respond to much lower concentrations of airborne fungal materials.
There was documented association, biologic plausibility, and apparent causality in specifically sensitized individuals.
Immunization against allergy is usually associated with therapeutic intervention in already sensitized individuals.
