Our method produced functional, sensitized CTLs that specifically induced U251 cell death in vitro.
To assay for a genetic interaction, we desired a sensitized background that is not completely polytene.
Next, we used transgenic CGRP-sensitized mice that have globally elevated levels of hRAMP1 (global hRAMP1) in all tissues.
Surprisingly, indomethacin-treatment of gluten-sensitized mice did not exhibit higher levels of antigen-specific proliferation compared to gluten-sensitized mice that were not given indomethacin (Figure 5).
"More and more people have become sensitized to that," he said, "and it's easy to get outraged".
In the sensitized rats that received control gavage, there were also no significant changes in threshold (p = 0.444).
However, in the sensitized rats that received ethanol gavage, significant differences in threshold were found across the three time points (p<0.001).
Priming is classically defined as the process by which the brain becomes sensitized such that administration of dopaminergic therapy modifies the response to subsequent dopaminergic treatments [3].
A similar response was observed in OVA-sensitized animals, indicating that OVA by itself can activate the stress axis.
