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Another key finding from this study is that the propensity of mice to reinstate was not correlated with the propensity to sensitize to a challenge dose of cocaine or the extent of CPP originally observed.
Similar(57)
The IgE-mediated immune response differs among sensitized subjects, even when exposed to a common environment; some individuals react towards a limited number of allergens (mono- or pauci-sensitized), whereas others are sensitized to a wide array of allergens (polysensitized).
However, with respect to sensitization, it is possible to become sensitized to a food at any age.
Previously, the T-cells of the mouse had been labelled with a fluorescein dye and sensitized to a protein from a tumor.
Hardly anyone is born subject to hay fever; to become a victim, one must become sensitized to a pollen or other allergen, usually by absorbing a large dose.
Now sensitized to a negative outcome, parents tended to hold back and not become as emotionally involved in a subsequent pregnancy.
The findings "make a lot of sense, given what we know about how the brain becomes sensitized to a traumatic event, and how there can be a cumulative effect," said Dr. Bruce McEwen, director of the neuroendocrinology laboratory at Rockefeller University, who was not involved in the research.
Male CF-1 mice that were pretreated with a single high dose of amphetamine (14 mg/kg intraperitoneally [IP]) or apomorphine (40 mg/kg subcutaneously [SC]) only became sensitized to a lower test dose of amphetamine (7 mg/kg IP) or apomorphine (3 mg/kg SC) when placed in an environment that was the same as the pretreatment environment.
Male CF-1 mice that were pretreated with a single high dose of amphetamine (14 mg/kg, IP) or apomorphine (40 mg/kg, SC) only became sensitized to a lower test dose of amphetamine (7 mg/kg, IP) or apomorphine (3 mg/kg, SC) when placed in an environment that was the same as the pretreatment environment.
Both were sensitized to a single mold (one Aspergillus, one Penicillium).
However, those examinations were performed by operators sensitized to a visual assessment of semi-quantitative pmeters.
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