Such elevation of monocytes may further sensitize the lungs to the second hits such as infection and high-stretch ventilation.
By inference from other chronic inflammatory conditions, one could argue that a chronic pro-inflammatory environment would be harmful, and could either directly promote age-associated decline in function, sensitize the brain to a second insult or even trigger a proteinopathy.
Upon entering tumor cells, miRNA-21i was released first to sensitize the cancer cells, the subsequent burst release of Dox was achieved by NIR triggered collapse of HGNPs.
The simulator was first used to sensitize the effect of changing the froth depth profile on target variables, and then to find out the best profile to reject common disturbances coming into the plant, considering some operating constraints.
The possibility that hyperglycaemia appears to sensitize the kidneys to the harmful effect of hypertension was first mooted in 1969 [ 42].
However, vascular thrombosis, accounting for 5% of early graft loss, can sensitize the recipient for human leukocyte antibodies, reducing the chance for a second transplant.
These could be trial balloons, meant to sensitize the Israeli public to less far-reaching concessions.
We postulate that the first minimal exposure to the chemical (5 months before admission) sensitized the patient, whereas the second exposure (9 days before admission) triggered the strong immunologic reaction that resulted in hepatotoxicity.
In 1998, Day and James [ 7] proposed a 'two hit' hypothesis to describe the pathogenesis of NAFLD whereby insulin resistance [ 8] contributes to steatosis (first hit), which sensitizes the liver to oxidative stress (second hit) leading to inflammation, fibrosis and necrosis.
Summarizing, as previously suggested by Savransky et al. [ 25], chronic intermittent hypoxia can be considered to predispose to liver injury sensitizing the liver to a second insult.
