Sentence examples for sensitize target from inspiring English sources

Introduction of the tricysteine motif, which does not exist in any wild-type PTP, serves to sensitize target PTPs to inhibition by a biarsenical compound, providing a generalizable strategy for the generation of allosterically sensitized (as) PTPs.

Here we report a novel strategy for the design of non-natural allosteric-inhibition sites in PTPs; these sites, which can be introduced into target PTPs through protein engineering, serve to sensitize target PTPs to potent and selective inhibition by a biarsenical small molecule.

Alternatively, other human cytokines not present in the HIS model might sensitize target cells to lower amounts of IL-7, but this also remains to be determined.

The effect of membrane potential may be to sensitize target proteins to HNE directly, for example, through a conformational change.

Fragments of the identified gene can then be transfected to define the region encoding the antigenic peptide, and finally candidate peptides bearing adequate HLA-binding motifs are tested for their ability to sensitize target cells to lysis by the CTL.

Further studies will be required to further elucidate the role of FGF-21 in glucose homeostasis and whether FGF-21 will sensitize target issues (liver, adipocytes, muscle) to insulin, as has been reported in animal models of diabetes.

In this model, sorafenib has no influence on rituximab-mediated ADCC indicating the possibility that sorafenib inhibits the activity of NK cells, and it simultaneously sensitizes target tumour cells to NK cell-mediated killing.

Having previously adapted a light-activated cation channel from green algae, channelrhodopsin-2 (ChR2), for sensitizing targeted neurons to temporally-precise excitation by pulses of blue light [18], we searched for a complementary optical tool that would enable simultaneously-and independently-controllable neuronal inhibition, driven by light of a second color.

This strategy utilizes a functionally silent active-site mutation to sensitize a target kinase to inhibition by a small molecule that does not inhibit wild-type kinases.

From this evidence, it can make sense to use the conventional chemotherapeutic agents in combination with other compounds that can sensitize the target cells.

Our data indicate that the single-agent effectiveness of docetaxel in the osteoblastic CaP environment may be limited, but ZOL may sensitize the target cells to the effects of docetaxel.