Perfect adaptation is a critical feature of many cellular signalling networks - it allows a cell to respond to a stimulus, but to re-sensitize itself so that further increases in stimulus can be detected.
The fact that MDMA sensitized to itself indicates that MDMA may have the potential to elicit dependency.
Exposure to certain viruses, bacteria, vaccines, or even myelin itself may sensitize the body's immune systems, which can trigger an autoimmune response on the nervous system [4].
Targeting EZH2 with drugs like GSK126 may not only induce apoptosis by itself but also sensitize cancer cells to other agents of chemotherapy.
The IL-17A-induced sensitization was prevented by neither etanercept nor sgp130; thus, IL-17A itself sensitizes joint afferents [ 54].
These data show that cell cycle arrest itself sensitizes towards TRAIL-induced apoptosis in the clear absence of protein regulation.
For the first time, we obtained mechanistic proof that cell cycle arrest itself sensitizes tumor cells towards TRAIL-induced apoptosis, including patients' tumor cells.
One future objective in this area is the continued development of EALL systems which operate at neutral pH rather than the strongly alkaline systems above which require addition of EDTA to avoid precipitation of the lanthanide hydroxide, because the EDTA itself sensitizes lanthanides to a small extent and contributes to the background signal.
Next, we aimed at discriminating between the different effects of p53 induced by cytotoxic drugs, and asked whether cell cycle arrest itself might be sufficient to sensitize towards TRAIL-induced apoptosis.
While multi-targeted approaches to sensitize GBM cells to TMZ and improvement of the drug itself are of interest, a better characterization of the molecular footprint associated with TMZ resistance is needed for such strategies to succeed.
Our observations are supported by previous evidence demonstrating that the introduction of NO donors or the overexpression of NOS could sensitize cells to Fas signaling, whereas direct treatment of ONOO− itself could also enhance Fas-induced apoptosis in leukemia cells.
