The first experiment was designed to reconfirm our previous observations that tetracycline and doxycycline bind selectively to PrPSc and sensitize it to protease hydrolysis [16].
We speculate that oxidation of the lysosomal Ca2+ channel during reperfusion may sensitize it to NAADP, in a manner similar to the redox regulation of RyR2.
Bcl-2 and Bcl-XL, the other anti-apoptotic member of Bcl-2 family, directly interact with the InsP3R on the ER membrane, and sensitize it to low agonist doses, promoting the leakage of Ca2+ from ER.
Rising levels of estrogens produced by developing follicles in the ovary feed back to the hypothalamus, amplifying GnRH pulses, and to the pituitary, sensitizing it to increasing GnRH.
Overexpression of LEF-1-ΔL might be a promising candidate for treatment of colon cancer by sensitizing it to chemotherapeutic drugs.
[laughs] I don't think there's any need anymore in our time and era for titles or brands... because either way you try to sensitize it, somebody's going to be offended.
"People rarely become allergic to the low levels of formaldehyde released by textile resins, but for those already sensitized, it is entirely possible to react to the low levels released by textile resins in clothing," she said, adding that some people were probably genetically predisposed to allergy.
First, severe pain from an injury or other stimulus, if continued over some period, was found to alter the neurochemistry of the central nervous system, thereby sensitizing it and giving rise to neuronal changes that endure after the initial stimulus is removed.
When a T cell encounters bacterial products, either directly or via presentation by a special antigen-presenting cell, it is sensitized to recognize the material as foreign, and, once sensitized, it possesses an immunologic memory.
You might try using Apture to provide that visibility (as well as other cross-linking capabilities.) Mostly, though, I was trying to point out a trend, and sensitize people to it, so that it doesn't creep up on them.
"Ultimately, players have to be sensitized to it.
