Nevertheless, the ZEB1-expressing line hPaca1 could be further sensitized to even very low gemcitabine doses by miR-203 and miR-200c overexpression.
In summary, we showed that MK2-deficient mice are highly sensitized to even very low doses of TNF, leading to hyperacute mortality.
To test whether GM1 could function as a receptor, exogenous GM1 was incorporated into host cell membranes, where it was shown to increase sensitivity to toxin, (Cuatrecasas, 1973) even sensitizing toxin-resistant cells (Moss et al., 1976).
Prolonged activation of meningeal primary afferents may even sensitize second order neurons of the nociceptive pathway in the caudal trigeminal nucleus [1, 2].
While, our findings suggest that a serine protease is a major contributor to PrP degradation, our data does not exclude the possibility that lichen secondary metabolites may function as cofactors for lichen enzymes or even sensitize PrP to protease digestion.
In contrast, mutp53-destabilizing therapies may impede or at least offset the adaptive responses, or even sensitize tumors to conventional cytotoxic therapies.
These data demonstrate that Caspase-2 deficiency does not hinder initial cell cycle arrest and apoptosis in response to chemotherapy, and may even sensitize tumors to apoptosis.
While this approach can not distinguish between the functions of individual AP-2 family members, it suggests that interfering with AP-2γ may sensitize to apoptosis even in the absence of functional AP-2α.
However, cell culture and animal and human trials results have shown that an important number of food constituents can lower cancer risk and even sensitize tumor cells against anticancer therapies [ 111].
The IgE-mediated immune response differs among sensitized subjects, even when exposed to a common environment; some individuals react towards a limited number of allergens (mono- or pauci-sensitized), whereas others are sensitized to a wide array of allergens (polysensitized).
