However, p53 has also been reported to be important in sensitizing a range of human cancer cells to DNA-damaging agents.
The program supports FSWs to collectively challenge structural factors underlying their risk and vulnerability, and attempts to build an enabling environment by sensitizing a range of stakeholders in and beyond the community level to address factors in the macro-level social environment that creates structural barriers to empowerment among FSWs.
In Zambia, community groups (for example, neighborhood health committees and safe motherhood action groups) were trained to sensitize communities about a range of maternal health topics in order to promote healthy behaviors and improve care seeking, including for MIP.
Thus, NANA sensitizes discharge over a range of smaller forces but not including those that trigger maximal discharge in seawater alone.
As well as RNAi-mediated downregulation of c-FLIP, RNAi-based reduction of Bcl-2, Bcl-xL, XIAP, and survivin has also been shown to sensitize cancers cells to a range of cancer therapies, including chemotherapeutic drugs and TRAIL [ 265].
This is particularly interesting when p21 and 14-3-3 14-3-3 14-3-3red because the loss of these proteins would sensitize cancer cells to a range of different therapeutic approaches, yet p53 (either wild-type or mutant p53) is able to drive the transcription of these genes in cancer patients.
These observations might be considered one aspect of evasive escape, because the serum Ang2 level is reported to increase at the time of disease progression in the clinic. 1 Our preclinical study suggests that the combination of lenvatinib and golvatinib sensitizes certain cancers through a range of mechanisms, which may allow the clinical dose to be reduced.
This interplay between CEBPB and DDIT3 may be relevant for glioma therapy development, as DDIT3 induction in response to a range of compounds sensitizes glioma cells to apoptosis (see, for example, [ 55]).
In these NP platforms, the host matrices tightly bind and sensitize a variety of Ln3+ ions allowing for a wide range of emission colors through selection of dopants.
