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It was reported recently that resveratrol could sensitize a number of cancer cells to the antitumoral effects of some conventional chemotherapy drugs.
In addition, it has been reported when it is used in combination with other anticancer drugs, resveratrol can avoid some of the debilitating side effects and sensitize a number of cancer cell lines to the anticancer actions of some other conventional chemotherapy drugs such as TNFα, paclitaxel, et al., as well as radiotherapy [ 5- 7, 9- 13].
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Even one or two bottles of a cow's milk formula may be enough to sensitize a newborn infant and cause an allergic reaction.
Activation of local CGRP receptors by exogenous CGRP sensitized a significantly greater number of joint nociceptors in MIA-treated rats than in saline-treated rats.
In the late AB subpopulation we also identified mutations in PIK3C2B and RPTOR, which may sensitize the tumor to a number of drugs that target the PI3K/Akt/mTOR signaling pathways.
Real experience working in startups sensitizes a board member to these realities of startup life.
In the process of aiming to sensitize MDR mediated by ABCG2, a number of ABCG2 inhibitors have been recently discovered [7], [8], [9], [10], [11], [12] in addition to the previously identified ones such as Fumitremorgin C (FTC) (for a review see [2]).
Withanolide E, a steroidal lactone from Physalis peruviana, was found to be highly active for sensitizing renal carcinoma cells and a number of other human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL -mediated apopTRAIL -mediated
It has been reported that HGF c-Met signaling induces or sensitizes apoptotic cell deatHGF c-Metmber of cell linesignalingng ovarinducescinora cell, breasensitizesmapoptoticouse sarcell cell andeathse hepatocarcinoma cell [ 16- 19].
The comparison of bladder fractions from resolved and sensitized mice revealed differential expression of a number of proteins (Fig. 4).
Although this sensitization worked reproducibly in a number of different hepatocellular tumor cell lines, we also found that primary human hepatocytes were equally sensitized to apoptosis induction by the combined treatment with TRAIL and doxorubicin.
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