"We need to have gender sensitization activities targeting to different levels... so that people don't experience stigma, whether it is from the decision maker, service provider, or community," suggests Aryal.
Recent studies consistently demonstrate that glutamatergic synapses not only play an important role in sensory transmission, including pain and itch transmission, but also contribute to nociceptive sensitization at different levels of the brain.
For instance, mild temperature hyperthermia has been proven to enhance sensitization to chemotherapy and radiotherapy through different mechanisms.
Downregulation of Mcl-1 leads to sensitization of tumor cells to different treatment regimens in vitro, as shown for cholangiocarcinoma, chronic myelogenous leukemia, sarcoma and malignant melanoma [ 23- 26].
This enhanced sensitization is not due to different migration properties of WT and Cytip-deficient BMDCs since Watford et al. demonstrated that both WT and Cytip-deficient BMDCs migrate equally after injection [ 8].
Several studies suggest that different brain areas and different mechanisms are associated with the development of sensitization to psychostimulant drugs such as nicotine [ 12].
However, when we downregulated ApoL2 using two different silencing sequences, we could not observe sensitization to cell death.
A similar overall allergen exposure can hide the heterogeneity in the sensitization to specific allergens in children or adults, which may vary in different countries.
The incidence of alleged human sensitization to chemicals has increased, in part, due to the fact that chemical companies are moving to larger and/or different markets.
