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The TiO2 NT array electrodes are sensitized with Mn-CdS and CdSxSe1-x QDs by employing a two-stage sensitization strategy combining successive ionic layer adsorption and reaction (SILAR) techniques and hydrothermal process.
This sensitization strategy involves the combination of linker-assisted assembly with in situ fabrication.
This sensitization strategy succeeds for both 'orthogonal' inhibitors, designed to be incompatible with wild-type PTP active sites, and previously optimized wild-type PTP inhibitors.
The characteristic of low radiation dose activity implies that this AND gate can be exploited as the targeted sensitization strategy in radiation therapy.
These results demonstrate that the 5-FU-mediated sensitization strategy is independent of p53, but based on p53 status, modified regimens have to be used with respect to the optimal time point of the TRAIL or MSC.sTRAIL administration.
Therefore, in order to assess whether this sensitization strategy would also be applicable in p53-defective tumor cells, we analyzed p53-mutated and p53-negative colon cancer cells, HT-29 and HCTp53−/− cells, respectively.
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These case reports reveal that recombinant forms of TRAIL, and possibly other TRAs, can be beneficial for individual patients even without additional sensitization strategies.
Further analysis on targets of miR-21 is still of considerable interest, as they may reveal novel radiotherapy sensitization strategies for radioresistant NSCLC.
UNICEF and its partners are working to refine their public-awareness and sensitization strategies – so that new infections can be prevented and health care workers can concentrate on treating those who are already sick.
The proposed co-sensitization strategy presented high sensitivity, reproducibility, specificity and stability, and also opened up a new promising platform for detection of other biomarkers.
In this review, we describe the current state of the PTP-sensitization strategy, with emphases on the methodology of identifying PTP-sensitizing mutations and synthesizing the compounds that have been found to target PTPs in an allele-specific manner.
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