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Performed researches revealed significant differences in the charge transfer resistance values recorded for the austenite grain interiors and the grain boundaries depending on the sensitization state.
In the human being there are two functional states, sensitization state and rest state.
Primary nociceptor neurons in a chronic sensitization state also perform efferent activities on injured tissues: the peripheral terminals of those neurons may release substance P and calcitonin gene-related peptide (CGRP) towards the injured site.
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A staff participant explained the importance of education and sensitization stating, " …because some of them have a misconception about HIV.
We have demonstrated that, in healthy volunteers, the mescencephalo-pontine reticular formation (MPRF), which projects to the RVM, regulates the expression of hyperalgesia in different central sensitization states.
Intrathecal SP induces sensitization of heat-evoked foot withdrawal in both species and in this sensitized state inhibition of either NK1 or NMDA receptors reverses the sensitization in naked mole-rats.
Importantly, nociceptive activity in peripheral tissues of FM patients does not necessarily have to be extensive, because central sensitization requires little sustained input for the maintenance of the sensitized state and chronic pain [ 26].
Activation and sensitization of dural afferents likely occur resulting in release of mediators that maintain the sensitized state and sustain pain.
As previously mentioned, when central sensitization has occurred in chronic pain patients, including FM patients, little additional nociceptive input is required to maintain the sensitized state.
The presentation of a series of relevant stimuli could be assumed to cause a state of sensitization.
However, the difference in behavior can also be ascribed to anxiety sensitization of a phobic state [ 90].
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