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However, it is believed that multiple mold sensitization skin test reactions are usually due to sensitivity to multiple antigens rather than cross reactivity [ 25].
During sensitization, skin DCs mature and migrate to the draining lymph nodes (LNs) where they present the hapten to naive T cells, which leads to the development of antigen-specific effector T cells [ 2].
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The risk of sensitization after skin testing was assessed in healthy volunteers.
To conclude, TRPA1 activation and sensitization mediate skin inflammation by increasing the release of inflammatory mediators, although their role in immune cells remains to be clarified.
One week following final sensitization intradermal skin tests and respiratory challenges were conducted.
ACD is also the most common manifestation of immunotoxicity observed in humans [ 13] and hundreds of chemicals have been shown to cause sensitization in skin [ 14].
Although initially used to evaluate induction of sensitization by skin exposure, recent studies describe its use for evaluating inhalation-induced sensitization (Arts et al., 2008; de Jong et al., 2009).
To avoid fatigue or sensitization of skin receptors, the stimulus locations were slightly varied from trial to trial, and the same spot was never stimulated twice within 1 minute.
However, some studies show correlation between exposure to fungi for example and sensitization, positive skin-prick tests and IgE antibodies [ 159 , 160]
In addition, both classes of sensitizers test positively on standard skin sensitization assays.
Skin lesions result from an abnormal sensitization of the skin to sunlight and tend to occur symmetrically on the exposed surfaces of the arms, legs, and neck.
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