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This model avoids the prolonged process of sensitization required for autoantigen-induced arthritis (e.g., collagen or peptide-induced arthritis), which makes it difficult to investigate the initiation of the diseases, and facilitates the investigation on the early inflammatory responses in immune-mediated arthritis.
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Importantly, nociceptive activity in peripheral tissues of FM patients does not necessarily have to be extensive, because central sensitization requires little sustained input for the maintenance of the sensitized state and chronic pain [ 26].
VV infection sensitizes TNF-resistant cells to TNF-induced cell death and this sensitization requires the presence of RIPK1 and RIPK3.
Expression of sensitization requires exposure to a challenge dose of a drug after a period of withdrawal subsequent to repeated drug administration.
We next investigated whether CDK9 inhibition-induced TRAIL sensitization requires activation of the mitochondrial pathway.
This form of sensitization is related to changes in the properties of primary nociceptive afferents (peripheral sensitization), whereas central sensitization requires functional changes in the CNS (neuroplasticity).
Sensitization requires exposure to protein allergens in the food although oral exposure is not the only route that can induce sensitization.
Sensitization effects observed at early withdrawal times are likely to rely on transient changes in receptor function [ 17- 19], whereas enduring sensitization requires long-lasting, perhaps permanent, neuroadaptations [ 19, 20].
In this regard, it is important to mention that many of the traditionally used semiconductors absorb only light energy or mostly in the UV region; hence, for a solar-driven process, dye sensitization is required [1].
Interestingly, although LPS during sensitization was required for lymphocyte infiltration after OVA challenge, higher LPS doses did not lead to increased lymphocytes.
A more complete understanding of the mechanisms governing MK-2206 sensisization is required to facilitate its therapeutic use in patients with cancer.
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CEO of Professional Science Editing for Scientists @ prosciediting.com