Sensitization of human renal carcinoma cells to TRAIL-induced apoptosis by withanolide E and its lack of toxicity were confirmed in animal studies.
Our study shows that auto-sensitization of humans with brain tissue can induce a disease, which closely reflects the pathology of MS, but that the mechanisms leading to demyelination and tissue injury differ from those, generally implicated in the pathophysiology of MS through studies in experimental autoimmune encephalomyelitis.
Sensitization to human leukocyte antigens (HLAs) remains one of the major clinical challenges for successful kidney transplantation.
Finally, progress has been made in the characterization of skin sensitization in humans and in the clinical management of ACD.
Thus, alum immunization is used in the study of asthma and allergy in animals, despite the questionable relevance of this adjuvant to the mechanism of allergen sensitization in humans (Eisenbarth, 2008).
But the study of sensitization in human subjects is complicated by the fact that most allergenic foods are normal components of the human diet; these foods are likely to be consumed in reasonably large quantities until allergic sensitization leads to elicitation of an allergic response.
In one of the latest efforts, Nagler's team first confirmed that mice given antibiotics early in life were far more susceptible to peanut sensitization, a model of human peanut allergy.
The aim of the study was to investigate the interaction between glutamate and capsaicin in inducing muscle pain and sensitization in humans.
As noted above, there is no good test to identify isocyanate sensitization in humans.
TRAIL sensitization of tumor cells, including human mesothelioma cells, by chemotherapeutic drugs has been well characterized [47], [48] and has been translated into therapeutic approaches involving soluble TRAIL or other TRAIL-receptor agonists [35], [49], [50].
Previous studies reported that PI3K/Akt activation protected human leukemia HL60 cells from TRAIL-mediated apoptosis, and the inhibition of PI3K/Akt augmented TRAIL sensitization in human leukemia, neuroblastoma, and colon cancer cells.
