Sentence examples for sensitization of cells from inspiring English sources

Inhibition of AKT activity in cancer stem cells also resulted in sensitization of cells to therapy and increased survival of mice bearing human glioma xenografts in vivo [11 14].

Sensitization of cells to DNA-damage induced apoptosis with the Bcl-2/BCLxL inhibitor ABT-737 did not overcome the protective effect of Bcl11b at low to intermediate concentrations.

ROS scavenging by ascorbic acid blocked the sensitization of cells by TM.

These data suggested that JNK is involved in the sensitization of cells for apoptosis induction.

Previous reports of sensitization of cells to ricin by proteasomal inhibitors used cLβ-l [ 24, 26, 33].

This data indicate that reduced Mcl-1 expression enhances the sensitization of cells to Bcl-xl inhibition.

In conclusion, we have demonstrated that extracellular S100A4 induces NF-κB transactivation and possesses proapoptotic activity through sensitization of IFN-γ-induced apoptosis, but whether activation of NF-κB is required for the observed sensitization of cell death is still unknown.

Additionally, several reports indicate that hyperthermia induces a strong immunological response via activation of immune cells and sensitization of tumor cells to immune effector cells [ 17- 19].

However, given that survival and death pathways are shared by normal and tumor cells, differential sensitization of tumor cells without affecting normal cells has been the goal to avoid the issue of toxicity to normal tissue.

Inhibition of IGF1 signaling was required for starvation-mediated protection of normal cells and sensitization of cancer cells to therapeutic drugs [ 22, 23].

These results indicate that protectors such as MEA could be preferentially protecting euoxic cells, and that combining such "oxic protectors" with a hypoxic sensitizer could result in protecting euoxic cells while the sensitization of hypoxic cells was not much reduced.