Sentence examples for sensitization in the context of from inspiring English sources

This secondary screen served two purposes: a) to confirm the primary screen results and b) to assay the extent, if any, of TRAIL sensitization in the context of caspase-8 or the catalytically inactive point mutant, where an attenuated, but measurable, effect is seen with MG-132.

PPARs form heterodimers with RXRs, which regulate the transcription of various genes implicated in promoting insulin sensitization in the context of obesity and the control of lipid metabolism, carcinogenesis and inflammation (15, 16).

The time-dependent nature of sensitization and kindling and the role of stress in the development of sensitization are discussed in the context of rodent models, with an emphasis on application of these models to human studies of MCS.

The fact that a translocation of TRPV1 channels from the cytoplasmic compartment to the plasma membrane is involved in sensitization is intriguing in the context of the role of sortilins in sorting and signaling.

Thus, in the context of nociceptor sensitization, it is tempting to consider the TrkA/sortilin vesicle as the signaling part, and the 'transducosome' as a potential long-term effector.

Based on this model, we investigated here the epicutaneous sensitization potential of Der p 2, specifically in the context of interaction with TLR4 and LPS, as well as the possible adjuvant function of a co-applied enzymatic allergen.

Maternal and newborn infant CD4+Ki67+ TNF-α+ T-cell frequencies were also positively correlated; this association was strongest in the context of maternal Mtb sensitization, but it did not persist at 16 weeks of age.

Awareness raising and sensitization of church leaders and groups are also important in the context of Manipur and Nagaland.

BKB2, though it has been implicated in nociceptor sensitization in OA [ 17, 19], may be less relevant as a therapeutic target in the context of a chronic inflammatory response.

While the downstream effects of antibody-sensitization of MCs have been well-characterized in allergy and hypersensitivity models, there is still a lack of understanding of how this process could be relevant in the context of viral infection.

The most relevant finding here is the reduction in KYNA levels, which, within the context of an enhanced release of glutamate might contribute to a hyperactivity of NMDA receptors resulting into nociceptive sensitization in CH.