For the AA patients additional information obtained included; allergy description, reporting clinician, re-challenge history during study period, de-sensitization history during study period and allergy/immunologist specialist referral.
As no information is available on the prevalence of asthma risk factors in Oman, we postulated that these findings may be due to differences in locally prevailing factors such as family history, sensitization to pollen and house dust mite, respiratory infections, and dietary habits, in addition to outdoor and indoor air pollutants including incense smoke.
An important point in studies on child's headache is the utility of clinical follow-up, in order to confirm migraine diagnosis and the significance of symptoms of central sensitization in the natural history of the disease.
Earlier detection and more accurate diagnostic tools raise new questions about the natural history of sensitization and granulomatous disease.
Table 3 presents the effect estimates of the association of mode of delivery with asthma and atopic sensitization stratified by family history of atopy.
As earlier mentioned, NO plays an important role in the history of central sensitization and, therefore, central sensitization caused by NO would be likely in patients with CFS.
The diagnosis of food allergy is largely reliant on medical history, tests for sensitization, and oral food challenges, but emerging use of component-resolved diagnostics is improving diagnostic accuracy.
(3) Amin et al. [ 99] in 2014 updated the original asthma predictive index by using the predictors of frequent wheezing, parental asthma, allergic sensitization to ≥1 aeroallergens, a history of eczema, wheezing without a cold, allergic rhinitis, and allergic sensitization to milk or egg.
Interictal photophobia could represent central sensitization due to a lengthy migraine history.
We also observed that the group of patients with TTH with higher sensitization levels also exhibited a longer history of headache, supporting this hypothesis.
