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SP administration would prevent the spinal circuit sensitization events described above from occurring and thus after i.t.
NGF signaling in pain has traditionally been thought of as primarily engaging the classic high-affinity receptor tyrosine kinase receptor TrkA to initiate sensitization events.
It would, of course, be interesting to determine in cellular systems whether sortilin or p75NTR participates in the fast sensitization events.
During household visits and through routine community sensitization events, CHWs educate communities on key health messages, including hygiene and sanitation, accessing care at facilities, malaria prevention, and general health.
Thus, increased peripheral NGF levels lead to increased production and release of BDNF from the central synapses of nociceptors in the spinal cord, and this may be critical for certain central sensitization events, especially those involving N-methyl d-aspartate (NMDA) receptors (Kerr et al., 1999).
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The public awareness campaigns that have been part of PEAR since it began should be strengthened, including demonstrations and sensitization at distribution events on key messages including hand-washing, use of mosquito nets, and education for school age children.
The ONB is thought to interfere with the subsequent sensitization developing during the event of acute headache attacks, modulating the excitability of second-order neurons receiving input from both trigeminal and cervical afferents upon stimulation of either afferent input [15, 16].
Allergic sensitization is a crucial event in allergic asthma.
UNICEF is providing vaccines and sensitization materials for this event, the first of its kind in the conflict-affected state, in addition to supporting the campaign's operational costs.
To ensure a mechanistic basis and cover the complexity, multiple methods should be integrated into a testing strategy, in accordance with the adverse outcome pathway that describes all key events in skin sensitization.
We also examined DDR events without BrdU sensitization [ 40, 47] and observed low-level GFP-UBF1 recruited to sites of DNA damage similar to that described by Bártová et al. [ 40] for GFP-OCT4 recruitment to DNA lesions.
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