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We observed that TNFα or IFN-γ alone exhibits minimal sensitization effects, but effectively sensitized metastatic colon carcinoma cells to TRAIL-induced apoptosis when used in combination.
Four of the 6 primary colon carcinoma cell lines (SW480, HT29, HCT116 and LS174T) are highly sensitive to FasL-induced apoptosis, and LCL85 exhibited minimal or no sensitization effects on these 4 sensitive cell lines.
The inhibitor of miR-101 (targeting ATM but not DNAPKcs) or miR-101* (targeting DNA-PKcs but not ATM) partially reversed the sensitivity of the cells over-expressed with miR-101, and combining the two inhibitors almost completely reversed the cell sensitivity (Figure 3C), confirming that the sensitization effects are derived from both strands of miR-101, which target both DNA-PKcs and ATM.
Futhermore, injection of CCL3 into mice spine cords enhances the sensitivity of the mice tails toward the hot water, indicative of chemokine-induced sensitization effects in vivo.
The sensitization effects were significant in an activity box as well as in an open field.
Some of these inconsistencies may be due to abnormal initial sensitization effects to startle-eliciting stimuli.
Similar(35)
This leads to lower sensitivity of the alloy against sensitization effect which appears at higher temperatures treatments of this material.
The enhanced sensitivity could be attributed to the chemical sensitization effect induced by the Au NPs, and the existence of conjugated depletion layers in the nanocomposites which promote a greater drop in resistance upon exposure to the gas.
The sensitization effect was found to occur only at the initial stage of the cool flame oxidation reaction.
The present series of experiments was designed to explore the persistence of the sensitization effect across the preweanling period.
Special attention has been paid to the sensitization effect of cadmium chalcogenides based nanoparticles (CdS, CdSe, CdTe) on TiO2 nanotubes in improving the efficiency of the solar cell.
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