Finally, based on the theoretical background and the findings in FM, the hypothesis concerning central sensitization in CFS will be unfolded, supported with the present knowledge on CFS.
The same difference between active and passive sensitization of animals is investigated concerning the antigen-induced late asthmatic response (LAR): LAR develops in actively, but not passively, sensitized guinea pigs [ 25].
Although sensitization to storage mites and other airborne allergens has been described, reports on sensitization to hog antigens have been inconclusive concerning the extent to which allergies contribute to the increased prevalence of respiratory symptoms in farm workers.
The knowledge concerning the physiological mechanism of central sensitization, the pathophysiology and the pain processing in FM, and the knowledge on the pathophysiology of CFS lead to the hypothesis that central sensitization is also responsible for the sustaining pain complaints in CFS.
A better sensitization for possible conflicts of interest in German publications concerning health services research is necessary.
Investigations concerning the effect of adjuvant and route of sensitization were all performed using Protocol 1 (see Fig. 1).
A third important argument in the central sensitization theory for CFS concerns the cognitive, psychological, and behavioral changes in patients diagnosed with CFS.
All present sterility tests concerning bacteria and viruses (including endotoxin) yielded negative results, and all evaluations of cell toxicity, sensitization, chromosomal aberrations, intracutaneous reactions, acute systemic toxicity, pyrogenic reactions, and hemolysis were negative according to the criteria of the ISO and the Ministry of Health, Labour and Welfare of Japan.
A trend emerges from each of these studies that shows how dissatisfaction with existing modes of practice, whether concerning policy, precept, or paradigm, when dealt with in a thoughtful, self-reflexive manner, as these specialists have all done, can serve to operate as a source of professional sensitization and open up transformational possibilities.
A questionnaire was conducted concerning symptoms of the upper airways (cough with and without expectoration, feeling tightness of the chest, breathless-ness), mucous membrane irritation of the eyes, nose, and throat, a history of cardiovascular diseases as well as airway sensitization.
