The prevalence of atopic diseases (allergic rhinitis, aspirin sensitivity, eczema), allergen sensitization based on skin prick tests, prevalence of other asthma-related comorbidities such as gastroesophageal reflux, obstructive sleep apnea, vocal cord dysfunction, anxiety and depression were not different between the Fixed Obs and Non-Fixed Obs groups (Table 2).
LCs were classically believed to act as the major APCs in CHS sensitization based on several findings [47] including incorporation of antigens [48], [49], correlation of CHS response with LC density at the sensitization site [50], presence of LCs with APC function in the LNs [15], and location of LCs at the surface of the body [51].
This discrepancy was even more evident when we evaluated the sensitization based on the number of years the migrants had spent in Singapore (Fig. 3D, Fig. S2B).
A home dust sample was also collected during the third trimester from subjects and analyzed for standard allergens relevant to maternal exposures and possible prenatal sensitization, based on evidence emerging from the Columbia PCS (Miller et al. 2001).
Interestingly, in the MIA-treated animals, secondary mechanical hyperalgesia developed from day 3 on and lasted for at least 14 days compared to secondary tactile allodynia, which was more pronounced during the early phase of arthritis development, reflecting an ongoing development of pain sensitization based on different molecular mechanisms during the 14 days after MIA treatment.
Current computational models to predict skin sensitization mainly based on in vivo assays without incorporating alternative in vitro assays.
In addition to providing datasets for developing computational models, SkinSensDB is equipped with browsing and search tools which enable the assessment of new compounds for their skin sensitization potentials based on data from structurally similar compounds.
The above intrinsic-extrinsic classification of sensitization is based solely on the induction process.
Windup is the LTP analogous mechanism at spinal cord dorsal horn level, leading to central sensitization at the base of chronic pain development and establishment [ 13, 14].
Momeni et al. (2010) obtained the optimal condition for the degree of sensitization (DOS) measurement based on double-loop EPR technique in H2SO4-containing KSCN solution by Taguchi method.
