This was done to determine whether MDMA can elicit behavioral sensitization as well as to cross-sensitize with other psychostimulants.
This phenomenon is dependent on stimulus frequency (⩾0.33 Hz) and relevant for central sensitization as well as chronic pain.
Using traditional learning paradigms, evidence suggests that spinal neurons support habituation and sensitization as well as Pavlovian and instrumental conditioning.
RGS9 knockout (KO) mice show increased psychostimulant-induced behavioral sensitization, as well as exhibit higher body weights and greater fat accumulation compared to wild-type (WT) littermates.
Our results suggest that 5-HT1B receptors may play a permissive role in the development, but not expression, of behavioral sensitization, as well as in the acute locomotor response to amphetamine in mice.
There are experimental results suggesting the role of PACAP in the development of peripheral sensitization as well in certain models of pain [78].
Activation of microglia and astrocytes contribute to spinal neuroinflammation [40, 41] and accelerate central sensitization, as well as development and maintenance of neuropathic pain [11, 12].
In order to develop an efficient titania-based visible light active photocatalyst, various methods have been reported such as doping with metals and nonmetals, dye sensitization as well as coupling with other semiconductors [9].
Conidia from the genus Aspergillus have been associated with allergic sensitization as well as exacerbation of allergy and asthma in otherwise healthy individuals [2], [3].
Animal and human studies have suggested that the NCF can inhibit and facilitate nociception through cholinergic and glutamatergic mechanisms, which may be triggered by noxious stimulation, central sensitization, as well as the expectation of pain.
We hypothesized that environmental estrogens would enhance allergic sensitization as well as bronchial inflammation and responsiveness.
