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Therefore, this medication leads to sensitization against food with changes typical for food allergy also in the intestine.
Most of the birth cohort studies found that cat or dog exposure in early life had no effect on the development of asthma or wheezing symptoms and dog exposure during infancy was found to protect children from developing sensitization against aeroallergens.
Yet, the detailed cellular and molecular mechanisms underlying sensitization against mechanical stimuli and the specific molecular components associated with these signaling events are not well understood.
Possible explanations for maternal sensitization against fetal HLA antigens would be: 1) recognition of fetal HLA antigens expressed in the remnants of trophoblasts or in the chorioamniotic membranes by maternal effector cells during the cleaning up of the uterine cavity after delivery [40], 2) feto-maternal hemorrhage [41], [42], and 3) fetal cell trafficking into the mother [43].
By preventing sensitization against these principal allergens, subsequent sensitizations can also be avoided.
The sensitization against different allergenic components can help to predict the possible severity of symptoms [ 15].
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In contrast, relevant sensitizations against common environmental allergens are rarely found in csU patients.
Moreover, the current use of extracts of undefined contents can lead to sensitizations against new allergens during conventional immunotherapy [2].
4 While the causal link between sensitizations against inhalant allergens for allergic rhinitis and asthma is clear, the exposure to these natural environmental antigens is considered less important when referring to the induction of relapses of the AE.
Especially with respect to TCIT of allergy, which is already investigated in clinical trials [6], researchers became aware of the importance of understanding the mechanisms of skin immune reactions in prophylactic as well as therapeutic settings in order to avoid therapy-induced side effects, or in the worst case, new sensitizations against therapeutically applied allergens.
We have previously shown that the presence of IFN-α at sensitization protects against subsequent antigen-triggered arthritis.
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