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Each sensitivity trial consisted of five to eight vials.
The one-dose sensitivity trial with EB was performed using the bioassay methodology detailed in [ 54].
Furthermore, in a single-blind sensitivity trial, using a proper cutoff value of 2.617, the miRNA panel correctly classified 103 of 108 (95%) NSCLC cases and 87 of 104 (84%) controls from an American cohort.
We identified a new five-miRNA panel in three independent cohorts from four centers in China and then validated the miRNA panel in a large cohort from America in a blind sensitivity trial.
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In the VOI framework, this approach can help prioritize further basic biological or preliminary clinical research by highlighting the sensitivity of trial outcomes to uncertainty in specific elements of the underlying biology or the linkages of that biology to phenotype.
Furthermore, survival benefit was not observed when other markers of septic shock were used for meta-regression analysis (table 4), and the septic shock subgroup itself was not robust to sensitivity or trial sequential analyses (online supplement).
The lower sensitivity in Trial 8 could in our opinion have been because the S. Dublin strain used did not grow so well in the second enrichment medium (TT-Hajna) used in the BAX® protocol, modified for optimal performance in faecal samples.
Each patient would have to determine personal sensitivities through trial and error.
In addition, we found no difference in terms of using a placebo arm to confirm the assay sensitivity between trials that were published in high-impact or low-impact factor journals.
A high sensitivity "therapy" (trials) filter was applied to the EMBASE search.
It is currently not available for clinical diagnostics due to the very high cost and undetermined sensitivity; clinical trials are pending.
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