The change in the energy spectrum of the decomposed wavelet signals of structural dynamic responses between the intact and damaged structures is used as the damage index due to its high sensitivity to the structural damage status.
Moreover, reconstitution of BRCA1 in the BRCA1 mutant HCC1937 breast cancer line or BRCA1-null UWB1.289 ovarian cancer cell line resulted in a reduced sensitivity to the DNA damage chemotherapeutic agents or ionizing radiation [50], [51].
For instance, reduction of BRCA1 expression results in increased sensitivity to the DNA damaging agents [48], whereas overexpression of BRCA1 increases resistance to the DNA damaging agents [49].
This result agreed well with previous reports that ku disruption in Neurospora crassa or Aspergillus fumigatus increased sensitivity to the DNA-damaging reagent (Ninomiya et al. [2004]; da Silva Ferreira et al. [2006]).
All the four mutants displayed high levels of sensitivity to the DNA damaging agents (Figs. 3B, 3C), compared to the wild-type, as reported earlier for the transposon induced recD mutant (CS1) of P. syringae [6].
Enhanced sensitivity to the chromosome-damaging effects of ionizing radiation is a feature of many cancer-predisposing conditions.
Tti2-F328S did not lead to sensitivity to the DNA damaging agents MMS or phleomycin, suggesting a minimal effect on Mec1 and Tel1.
Strains mutant for top3 have pleiotropic phenotypes including severe growth defect, hyper-recombination at multiple loci, and sensitivity to the DNA damaging agents MMS and HU.
Furthermore, Δrho3 cells also exhibited cell wall-integrity defects as judged by the sensitivity to the cell-wall damaging agent, micafungin an inhibitor of (1,3 -β-D-glucan synthase.
Conversely, low PON1 levels are associated with an enhanced sensitivity to the development of liver damage [ 9].
