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This includes incorporating data-derived estimates of the degree of inter- as well as intraspecies differences in sensitivity to identified causal events in a hypothesized MOA during risk evaluation.
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Therefore, the bioassay specificity and sensitivity to identify the investigated bioactivity are important criteria in EDA.
Additionally, by using a lower cutoff, the sensitivity to identify patients with HH could be increased.
For example, questionnaires may differ in their sensitivity to identify cases where respondents consider their symptoms trivial.
By using such a threshold to other uricase pairs, the comparison of specific activity always gave higher sensitivity to identify positive candidates than the comparison of activity concentration.
Besides, the Electrochemical Noise technique demonstrated sensitivity to identify corrosive process variations even in conditions considered to be of very low severity.
These severe H5N1 infections were diagnosed by using criteria developed by the WHO that are specific for H5N1 disease but that lack the sensitivity to identify the total number of human infections (table S1) (3).
EVH has a relatively high sensitivity to identify EIB and a high negative-predictive value [27].
We then used mRNA signatures of chemotherapy sensitivity to identify alternative therapeutics for patients resistant to TFAC.
A limitation for this study is that changes in brain metabolism, which average activity over 30 minutes, may lack the temporal sensitivity to identify the dynamic changes in brain activity elicited by cue exposures as detected with fMRI.
The sensitivity to identify patients with diffuse SSc amounted to 60%.
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