One hundred and fifty-eight clones from the PL and BM of 11 women were compared for their sensitivity to the entry inhibitors to Tak-779 and T-20.
PL and BM full length Env from 11 women (5 of whom had PL and BM sequences which initially scored as compartmentalized under the previously mentioned tests) were compared for their sensitivity to the entry inhibitors Tak-779 and T-20 using the TZM-bl single-cycle pseudotype assay as previously described [56].
In summary, the sensitivity to the Ca2+ entry blockers Gd3+ and SKF-96365 is in favour of the concept of capacitative Ca2+ entry, secondary to store depletion by 8-Br N-cIDPR.
Several sequence motifs which signal either sensitivity to proteolysis or entry into degradation pathways have been determined [35].
Sensitivity to several post-entry restriction factors maps to CA, indicating that some CA protein remains associated with the reverse transcription complex after entry81.
Therefore, it is reasonable to expect that pretreatment of prostate cancer cells with 1 α,25(OH)2D3 and 19-nor-1 α,25(OH)2D2 will increase their sensitivity to IR by inducing the entry of the majority of the cells in these two radiosensitive phases.
We also investigate the effects of changing important parameters, including reproduction numbers in non-local visitors to Hong Kong, screening sensitivity at entry border points, and date at which travel restrictions are imposed.
Interestingly, CRAC currents displayed a somewhat higher sensitivity to Pyr10, as expected from Ca2+ entry measurements.
There has been increased interest recently to develop approaches based either on activating quiescent cancer stem cell to induce their cell cycle entry and increase their sensitivity to other treatments, or identifying agents that are capable of directly targeting quiescent cancer stem cells [ 21, 22].
Similarly, a comparison of the envs from two primary isolates of HIV-1 demonstrated that the reduced fitness associated with a clade C Env was associated with weak cell surface binding, inefficient entry, and an increased sensitivity to CCR5 antagonists and fusion inhibitors [ 20].
