These findings suggest that the drug could improve conscious control over instinctual drives; alternatively, it could increase the sensitivity to alterations in hunger and satiety, helping people with initial high levels of hunger urges to improve control on food intake.
For example, we utilised the clinically approved low molecular weight gadolinium contrast agent Magnevist, sensitive to changes in both vascular permeability and perfusion, whereas others have used a macromolecular contrast agent providing greater sensitivity to alterations in vascular permeability alone (Jordan et al, 2005b).
Due to its high transverse relaxivity (∼100 m M−1 s−1, at 7 T (Gambarota et al, 2006)), USPIO provides an extremely high sensitivity to alterations in local tissue blood volume; as a result, it generates a high signal contrast in T2*-weighted images between regions of different blood volume.
In practice, the distribution and length of the spotted array elements determine the detection sensitivity to various alteration sizes with some recent platforms being able to detect alteration sizes less that 100-kb [ 2].
Our analysis demonstrated major differences in the target genes of HS between wild-type and PPARα-null strains indicating that in the absence of PPARα, major changes in chromatin accessibility to HSF1 and other factors leads to greater sensitivity to HS alteration.
The efficacy of paclitaxel can be attenuated by the overexpression of multidrug efflux transporters, altered metabolism, decreased sensitivity to apoptosis, alterations in microtubule dynamics, diminished interactions of paclitaxel with its cellular target, and genetic polymorphisms [ 1, 2].
A unique facet of epigenetic marks that distinguishes them from their genetic counterparts, is their sensitivity to undergo alterations in response to dietary and other environmental exposures [1], [3], [4].
Multiple imaging biomarkers such as T2 mapping, T1rho, and dGEMRIC demonstrated sensitivity to biochemical alterations of cartilage repair tissue.
Here, we present a wide-field optical scatter imaging modality with sensitivity to dynamic alterations in size, shape, and orientation of sub-micron structures to investigate early apoptotic changes.
P53 protein is the product of one of the most frequently mutated tumour suppressor gene in cancer and also an important determinant of tumour cell sensitivity to DNA alterations including those induced by genotoxic drugs (Lowe and Lin, 2000; Lowe et al, 1993).
