To assess model sensitivity to the data aggregation time period we conducted analyses where outcome and exposure data were aggregated at the calendar month level.
The structures of the mature amyloid fibrils, the presence of oligomeric intermediates in electron micrographs at early incubation times, and the sensitivity to HTTNT inhibition of aggregation strongly suggest that these full-length HTT exon1 analogues aggregate by the same two-step mechanism deduced for C-terminally truncated HTT exon1 peptides.
The strong salt dependency described here is another example of the high sensitivity of αS fibrillization to aggregation conditions, besides previously described factors such as pH70, temperature6, and the presence and type of surface71 or phospholipid membrane72.
The WT-GFP tag suffers from low fluorescence, comparative dimerization, aggregation, and high sensitivity to pH, making it inefficient.
Despite their slower growth, spheroids formed by budding or aggregation initially showed sensitivity to cytotoxic drugs that was equivalent to monolayers.
In concert with the stress response transcription factor, Heat Shock Factor 1 (HSF-1), DAF-16 regulates the formation of toxic protein aggregation, reduces the sensitivity to stress and increases lifespan in C. elegans [ 2, 3].
This λ max shift to a larger value and the excessive broadening can be attributed to the increased crystallite size of the nanoparticles due to particle aggregation which decreases the sensitivity to plasmon response [5].
The Gini index has a number of limitations in the context of health benefits analysis (Levy et al. 2006) but allows us to consider sensitivity to the approach for individual comparisons and aggregation.
They share two important features that suggest sequence-specific aggregation: oligomeric intermediates as precursors to the aggregated sate and sensitivity to site-specific point mutations.
Because malignant cells have higher protein synthesis rates than normal cells, they may be more prone to protein aggregation and proteotoxicity and possess increased sensitivity to bortezomib-induced apoptosis.
