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We have learned that bias and sensitivity rules are subject to expansive interpretations.
Application of the FICTS sensitivity rules [26] gave us further insight.
This raises an important question of how to minimize the effects of conflicting sensitivity rules, and hence improve confidence intervals.
Primers were designed by the rules of highest maximum efficiency and sensitivity rules were followed to avoid formation of self and hetero-dimers, hairpins and self-complementarity (see Additional file 2).
The higher threshold, with an inherently increased specificity, rules in GDM; the lower threshold, with its innate increased sensitivity, rules out GDM. Women who have FPG values in between these two thresholds are indeterminate and would need the diagnostic OGTT.
In simple cases, such as this network, a single tracer and a single measurement may be capable of resolving all free fluxes with high fidelity; however, as the number of free fluxes increases in a network, not all sensitivity rules for each flux can be satisfied, resulting in smaller magnitudes of isotopomer sensitivity and loss of confidence in the estimated flux values.
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We remain unit-economics driven and price sensitive, but will bend that price sensitivity rule if the company is growing by leaps and bounds and we can reasonably expect it to grow into its valuation – especially with the capital that it is raising.
To increase the practical utility of TE, we calculated cut-off point with 100%% specificity (rule in) or 100%% sensitivity (rule out) of liver and spleen stiffness for CSPH and SPH.
A two cut-off value strategy, with one using a lower cut-off value to optimise the sensitivity (rule-out value) and the other using a higher cut-off value to optimise the specificity (rule-in value), would make better use of the information that a biomarker with a continuous value could provide.
("SNOUT": SeNsitivity-rule OUT).
The sensitivity condition rules out this belief as knowledge only if, were there no barn there, Henry wouldn't have believed there was.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com