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Separate models also adjusted for platinum therapy sensitivity (resistant, sensitive, too early or missing) and treatment response (complete response, partial response, progressive disease, stable disease or missing).
Also, when we divided the AML samples in three subgroups based on their in vitro ara-C sensitivity, resistant patients expressed three-fold lower hENT1 mRNA levels compared to sensitive patients (P=0.003; Figure 3).
Apart from oseltamivir sensitivity, resistant and nonresistant strains were assumed to be similar.
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The trial was stratified based on platinum sensitivity (platinum resistant versus platinum sensitive) and Eastern Cooperative Oncology Group performance status (0 1 versus 2).
We suggest that it might be possible to do so by manipulating the environment in a way that increases the sensitivity of resistant mosquitoes to insecticides and that increases the evolutionary cost of resistance.
In conclusion, our results demonstrated that shRNA expression vectors could effectively reduce NPM expression and restore the drug sensitivity of resistant leukemic cells to conventional chemotherapeutic agents.
YC137 inhibits BCL-W and BCL2 and restores ICI sensitivity in resistant cells.
Restoration of ICI sensitivity in resistant cells appears to occur through an increase in autophagy-associated necrosis.
Inhibition of HB-EGF and the addition of miR-212 mimic induced cetuximab sensitivity in resistant cell lines.
These results suggest that BCL-W+BCL2 coinhibition can increase antiestrogen sensitivity in resistant breast cancer cells by preferentially activating necrosis, apparently in association with the induction of autophagy.
Triterpenoids also restore the sensitivity of resistant tumor cells to TRAIL [19], [21], TNF [27], [29] and chemotherapeutic drugs [26], and are well tolerated by mice [13], [14], [18], [21].
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