Just as statistical power can be thought of as the sensitivity of a trial, the specificity of clinical trials is generally set to be 95%, based on the conventional significance threshold of P<0.05.
This scale takes into account not only the quality of blinding (trials have to be randomised), but also trial size, the validity or appropriateness of outcomes, baseline characteristics of patient groups to ensure sensitivity of the trial, and the quality of data analysis.
Parts of the two-month trial at the Old Bailey were held in secret for national security reasons, allegedly at the request of MI6, although no further explanation for such sensitivity of the trial was given.
Given the high political sensitivity of the trial against Bo, it is very likely that the central politics and legal affairs commission agreed in advance how severely Bo should be punished.
"It may directly contradict a bit of Maxine's story, if not the actual facts, the way she has told it," said the person, who did not want to be identified because of the sensitivity of the trial.
The positive control group is essential to define the sensitivity of the trial to detect a drug's effect on cardiac repolarization.
Nevertheless, some reasons explaining the past and present elevated placebo use include: it maximizes assay sensitivity of a trial; therefore amplifying the signal [56]; placebo-controlled studies need smaller sample sizes [13] and the relatively low risk of using placebo in psychiatric trials for short periods of time [57].
Moxifloxacin administration resulted in a clinically significant increase in QTcF, thereby establishing the assay sensitivity of the trial.
In addition, in a prespecified, exploratory manner, celecoxib was assessed versus placebo to examine the sensitivity of the trial.
The corollary of this, that the case number for any one surgeon was comparatively low, might have reduced the assay sensitivity of the trial.
