Sensitivity of the screening procedure was 99.3%.
However, we did not include screen-negative participants in the validation study, so cannot determine the sensitivity of the screening question.
Given sensitivity of the screening test, we derive likelihood expressions to simultaneously estimate (1) the rate of onset of preclinical cancer, (2) the average preclinical duration of progressive cancers, and (3) the fraction of preclinical cancers that are indolent.
The sensitivity of the screening question would then be 0% (Figure 3).
Mean estimate for the sensitivity of the screening instrument was 69%; and for specificity 94%.
Moreover, our study is not assessing the sensitivity of the screening questions to define a TB suspect.
To calculate the decrease in alcohol consumption due to SBI we multiplied the sensitivity of the screening instrument by the decrease in alcohol consumption times the long term maintenance fraction.
To the extent that asymptomatic anorectal STI could be present for longer than 1 month, the sensitivity of the screening question would be further compromised by risk behaviors resulting in transmission prior to the 1 month window.
The sensitivity of the screening question for self-reported exposure to predict anorectal STI was higher in the primary care than in the HRA clinic, 86 100% vs. 12 35%, respectively.
We believe it is unlikely that patients would over-report sexual risk behaviors in either clinical context (tending to decrease the specificity of the screening question) but would rather tend to under-report risk behaviors in both settings (tending to decrease sensitivity of the screening question).
Moreover given that Rabankyrin-5 is a Rab5 effector, the significantly higher levels of macropinocytosis in Rabankyrin-5 overexpressing cells relative to those overexpressing Rab5 demonstrates the sensitivity of the screening assay in detecting the quantitative difference between modulating upstream and downstream components of the macropinocytic pathway.
