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Implications of the findings for meta-analytical treatment research, for designing effectiveness studies, and for future research on the treatment sensitivity of outcome measures are discussed.
The Global Mood Scale (GMS; [Denollet, J., 1993a. Emotional distress and fatigue in coronary heart disease: the Global Mood Scale GMSS). Psychol Med 23, 111 121., Denollet, J., 1993b. The sensitivity of outcome assessment in cardiac rehabilitation. J Consult Clin Psychol 61, 686 695.]) was originally developed as a measure of positive affect (PA) and negative affect (NA) in cardiac patients.
Sensitivity of outcome ascertainment was thus not the same across exposure levels and one would expect that hazard ratios for these exposures might be biased [ 23].
This form of a HTQ is routinely used to assess the sensitivity of outcome measures in medicine [ 53, 55] and more specifically patients with arthritis [ 54].
Although this small sample precludes drawing conclusions on intervention effects or determining sensitivity of outcome measures, our case series provides rationale for future feasibility studies.
The IMPACT studies have addressed methodological issues of trial design in TBI with an emphasis on dealing with the population heterogeneity and increasing sensitivity of outcome analysis [ 107] (Box 3).
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However, we want predictions that reflect the sensitivity of outcomes to small changes in the merit scores.
Table 11 reveals the sensitivity result of outcome ATT values to the dummy confounder.
Responses to devalued outcomes, or slips of action, imply a lack of sensitivity to outcome value and are therefore indicative of the dominance of habitual response control.
It is likely that the nature and direction of bias in the included studies would tend to over-estimate effect size, favouring the interventions of interest, although the lack of sensitivity of some outcome measures would tend to reduce the apparent intervention effect.
To quantify the sensitivity of the outcome variables to each parameter, we calculated a partial rank correlation coefficient between each parameter value and each outcome variable (40- 47).
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