Among the 6 genes, the knockdown of topo IIα significantly affected the sensitivity of cells to etoposide (Fig. 2B).
ROC and other rocaglates have been reported to affect a number of cellular phenomena that have also been reported to affect sensitivity of cells to TRAIL.
In this article, we demonstrate that the shear sensitivity of cells may be one of the main causes.
An increasing number of reports emphasize the high sensitivity of cells to the physical characteristics of the surrounding milieu and in particular, topographical cues.
In contrast, cell surface expression of αVβ3 or mRNA for the β1, β3 or β5 subunits did not appear to contribute to sensitivity of cells to FMDV.
As measured by constant-field gel electrophoresis (CFGE), DSB induction, but not residual DSB exhibited a significant correlation with the sensitivity of cells to CIS.
One of the hallmarks of type-2 diabetes is decreased sensitivity of cells to insulin.
O6-Benzylguanine (BG) inactivates O6-alkylguanine-DNA alkyltransferase (AGT), resulting in an increase in the sensitivity of cells to the toxic effects of O6-alkylating agents.
Various lines of evidence suggest that the sensitivity of cells to this drug is directly related to the topoisomerase I content.
Alternatively, there may be ways to increase the sensitivity of cells to temperatures that can be achieved currently, such as pH reduction or chemosensitization.
Therefore, age- and species-dependent cellular parameters may influence the sensitivity of cells towards depolymerizing effects of colchicine.
