However, this does not rule out the presence of amyloid plaques in this structure, since a higher-sensitivity method to detect immunoreactive amyloid protein was not used.
Although it was found that there was very low sensitivity for detecting small CNVs, no length filters were chosen as filtering on length was found to decrease the sensitivity of the method to detect longer CNVs.
Additionally, there might be differences in the sensitivity of QCT method to detect changes in bone at different measurement sites.
In total hence we simulated 4500 MSAs to study these three effects on the sensitivity of the method to detect coevolution.
In the final validation exercise, sensitivity of the method to detect de-escalation events in the vignettes was highly dependent on the addition of PO credits.
Using these cut-off values, the sensitivity of the method to detect minor psychiatric disorders is 83.5%, and the specificity is 80% [ 2].
We also examined and tested when the coevolutionary relationship between a pair of amino acids is sufficiently strong as to overcome the effect of background noise or limited MSA size on the sensitivity of the method to detect coevolution.
We simulated MSAs using a model similar to that devised by Pollock et al. [ 2] as to avoid biasing the sensitivity of our method to detect true coevolving pairs due to the method employed in the simulations (avoiding then the circularity in our approach).
However, in 29.3% of the patients, we found that decoding of forearm movements was biased to upper arm muscle activity and not forearm extensors, which indicates that in these patients either there was no residual EMG activity on the forearm extensor muscles or not enough sensitivity in our method to detect it.
The sensitivity of our method to detect exceedingly low counts of target ctDNA could be improved linearly by increasing the amount of input DNA into ddPCR reactions, by multiplexing, by preamplification, and/or by isolating circulating DNA from a larger volume of plasma.
SEPT9 in plasma, on the other hand, displays a high degree of sensitivity and sensitivity, making it a better method to detect CRC than guaiac-based FOBT and CEA but it is still very limited for the detection of adenomas [ 5– 7].
