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Over the past few decades, microfluidic devices have emerged as an effective platform for various bio and chemical analyses (e.g., point-of-care testing [1], dynamic microarray [2 4], single-cell analysis [5 7]) because of their numerous benefits, including reduced fluid volume, rapid analysis, high sensitivity, massive parallelization, and portability.
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Obese mice overexpressing adiponectin, for example, have normal insulin sensitivity despite massive obesity, further supporting this notion.
Thus, the modulation of expression and secretion of these miRNAs in AT, particularly in adipocytes, may contribute to the improvement of insulin sensitivity following massive fat mass loss and decreased inflammation.
Increased TRAIL sensitivity explains why massive T cell expansion is not necessary and why type-I IFNs are not required for the anti-tumor effect in our model.
"We have to be aware that Russia had significant losses during the war and there are massive sensitivities.
"As a less mature market with a strong service culture and price sensitivity, Brazil offered a massive opportunity in the SMB segment - but that would only be unlocked with a massive education exercise," he adds.
Even with such extreme sensitivity, only the most massive and violent events out there would be loud enough to make the detectors ring.
In case of overexpression of an IL-6 gene variant with extreme sensitivity to IL-1β, massive release of the cytokine from undifferentiated tumour cells may accelerate progression towards malignancy by paracrine action on more differentiated tumour cells with a still functioning proliferative IL-6 signalling pathway.
Nevertheless, many people claiming to suffer from non-celiac gluten sensitivity issues have reported a massive improvement in their symptoms after eliminating gluten from their diet.
After this sensitivity analysis we found that massive hydraulic fracturing treatment is required for Fig 16 in order to achieve long half-length and high fracture conductivity.
At a sensitivity of 90%, specificity for massive transfusion was only 50%, with 58% of patients correctly classified.
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CEO of Professional Science Editing for Scientists @ prosciediting.com