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In the "sound" condition, the average amplitude of the heart rate response differed significantly between noise-sensitivity groups: the low sensitivity group showed a lower average amplitude of heart rate response than the high sensitivity group.
At the end of the day, I had to keep in mind that it's a business, not a sensitivity group.
In order to investigate which UCN-01 target(s) was involved in GSC death, we treated three GSCs lines for each UCN-01 sensitivity group, and analyzed the levels of total and phosphorylated PDK1 (S241), PKC αμ βII (T638-41), CDC25C (S216), and CDC2 (Y15).
In addition, to evaluate the relative impact of target inhibition by UCN-01, we treated three GSC lines, one selected from each UCN-01 sensitivity group, with small molecule kinase inhibitors directed against PKC, PDK1, or CHK1 and performed an in vitro drug combination assay (Supplementary Figure S7).
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‡As in previous tables sensitivity groups are compared with sensitive group given antibiotics as comparison group.
Based on Cihal rating about the sensitization of materials[23], the samples can be classified into four sensitivity groups: unsensitized samples (for DOS <2%), samples which are traces of sensitization (for DOS values between 2% and 8%), samples which are considered weakly and medium-sensitized (for DOS values between 8% and 30%), and samples which are severely sensitized (for DOS >30%).
Twenty-five subjects were classified into three PROP sensitivity groups (non-tasters, tasters and super-tasters) based on their bitterness ratings of a 0.32 mM PROP solution as measured on a Labeled Magnitude Scale (LMS).
The medium-sensitivity group displayed intermediate molecular patterns and, at the highest concentration of UCN-01, GSCs from diverse sensitivity groups clustered much closer.
The AAC codon, which does not belong to any of the sensitivity groups, is a member of the insensitive group.
The subsets with high and intermediate sensitivity (groups A and B) are enriched for cells with Luminal and ER+ phenotypes.
We classified GSCs into three sensitivity groups, that is, low, medium, and high, based on the relative efficacy of UCN-01.
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