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It can be assumed that the reported depressiveness/anxiety is associated with a higher sensitivity for pain symptoms, a biased attention towards pain and a rather dysfunctional evaluation of pain (pain catastrophizing) [69, 70].
c) Factors contributing to this variation include the pain threshold of the woman, the radiographer's sensitivity for pain expression, the uncertainty or inaccuracy in estimating the pressure on the breast, the radiographer's opinion of what is a good compression, and local conventions.
Additionally, inadequate coping with headache as well as depressive cognitive styles, both associated with negative self-instructions, a rather anxious-negative and biased attention towards pain, an increased sensitivity for pain, and tendency to ruminate about pain seem to heighten the probability of increased headache frequency and a corresponding pain-associated disability [70, 75].
One example is the catechol-O-methyltransferase polymorphism in which the sensitivity for pain is increased [ 56, 57].
A topic of increasing interest in recent OA research is the genetic variation in OA patients with respect to sensitivity for pain; a variation that might indicate a different need of pain management.
Fear of injury has also been suggested as a potential predictor of disability in CRPS [ 115], and combined with increased sensitivity for pain, fear of injury may lead to excessive guarding and over-protective behaviors [ 116].
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A recent study revealed distinct somatosensory profiles in CBP and FMS: FMS patients showed increased sensitivity for different pain modalities in all measured body areas, which suggests central disinhibition (or a deficient pain inhibitory system) as a potential mechanism.
This result confirms the results of a previously published [ 108] study indicating a higher sensitivity for identifying pain in the cervical region compared to the lumbar spine.
Older females exhibited lower pain detection temperatures than men (increased pain sensitivity) for both mild and moderate pain, suggesting a greater ability to detect and identify painful stimuli than their male counterparts.
Optimal sensitivity and specificity for pain and functional improvement was estimated via ROC at 4 × 10 cells, and served as the value to discriminate between the higher and lower cell count groups (Fig. 1).
Another SNP in SCN9A gene causes greater sensitivity for those with pain caused by osteoarthritis, lumbar disc removal surgery, amputee phantom limbs and pancreatitis.
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