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Whole genome sequencing provides greater sensitivity for defining translocation events (Chen et al. 2013), and this was illustrated by Welch et al. (2012) in their analysis of a case of acute promyelocytic leukemia (AML) where no chromosomal abnormalities were cytologically visible.
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In designing a microsensor of desired sensitivity, it is important to know the effect of each dimension on the sensitivity for properly defining the sizes and shapes of the microsensor.
Targeted approaches for protein quantification have been developed to produce accurate and high-sensitivity data for defined subproteomes.
Faint staining may be considered non-specific leading to higher sensitivity and lower specificity for defining MMR deficiency, or vice versa.
The high-aspect-ratio domain requires a large finite element mesh for simulating electric fields and for defining spatial sensitivity responses of electrode pairs.
Interactive use is supported by a large collection of graphical user interfaces for model writing and compilation diagnostics, defining input functions, model runs, selection of algorithms solving ordinary and partial differential equations, run-time multidimensional graphics, parameter optimization (8 methods), sensitivity analysis, and Monte Carlo simulation for defining confidence ranges.
> Figure 3 (left and middle panels) shows the achieved specificity and sensitivity for all defined feature sets.
Sensitivity for hyponatremia defined as serum sodium < 136 mmol/L was 3.5%; specificity was greater than 99%.
When this is done, good quality studies show a sensitivity for CHD defined angiographically as high as 90% and a normalcy of 89%.
A previous study [40] recognized the potential importance of canal vector (length and projection angle) for defining directional electrosensory sensitivity and noted that the dorsoventrally flattened batoids have very short canals that project in the vertical plane.
Sensitivity analyses using a different threshold for defining small trips and including trips to convenience stores found similar results, however.
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