Sensitivity analysis entails varying the parameter values of key assumptions underlying the estimates to assess the robustness of the findings or conclusions.
For example, a desired sensitivity of 60% entails declaring a threshold for positivity corresponding to a probability of late anemia of 22% or more (T'), resulting in 34% of the population exceeding this predicted probability and thus being considered at risk for late anemia (P') and potential candidates for intervention.
Bortezomib treatment did not cause any increase in nuclear foci containing phosphorylated histone H2AX, and knockdown of BRCA2 did not entail sensitivity to bortezomib, suggesting that the DNA repair function of BRCA1 may not be directly involved.
Our calculations show that increasing network complexity entails increasing sensitivity of predicted flux distributions to variations of standard Gibb's free energy changes and metabolite concentration ranges.
The methods entail global sensitivity analysis for retaining important PDD component functions, and a full- or sparse-grid dimension-reduction integration or quasi Monte Carlo simulation for estimating the PDD expansion coefficients.
In this subset, the best cut-off point was 3.26, entailing a sensitivity of 89 % and a specificity of 72%%.
Improvements of the molecular serotyping assays would entail increased sensitivity and inclusion of targets for all serotypes/serogroups.
Hence, the fact of having the first child at an early age may entail lower sensitivity of differentiated mammary tissue to the action of mitogens and mutagens.
Ultimate goal of clinically-oriented cancer simulation models is their eventual translation into clinical practice, which entails a) thorough sensitivity analyses, in order to both comprehend and validate their behavior, and at the same time gain further insight into the simulated mechanisms, in a more quantitative way, and b) an adaptation and validation process based on real clinical data.
One way of achieving high sensitivity in luminescence-based assays entails the use of time-resolved luminescence measurements to minimize the sample background.
